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Cephalexin

Cephalexin is an oral antibiotic with wide spectrum activity against variety of bacterial infections, which include pharyngitis, otitis media, osteomyelitis, cystitis, pyelonephritis, prostatitis, streptococcal and staphylococcal skin infections etc. Cephalexin is not used to treat viral infections and mycoses (infections caused by fungi).

Other names for this medication:
Cephadex®, Sporidex® DT, Sporidex®, Ceff®, Cephalkem®, LX®, Phexin®, Cephaxin®, Equitrol®, Cefter®, Oriphex®, Cefbact®, Rofex®, Staphydex®, Keflex®, Alcephin Px®, Alexin®, Cefacure Af®, Ecef-Od®, Mexef®, Sporidex Af®, Daxbia®

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Cefaclor, Raniclor, Cefadroxil, Duricef, Cefazolin, Ancef, Cefdinir, Omnicef, Cefditoren, Spectracef, Cefpodoxime, Vantin, Cefprozil, Cefzil, Ceftibuten, Cedax, Cefuroxime, Ceftin, Cephradine, Velosef

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Description

Cephalexin tablets comprise Cephalexin as an active ingredient. Cephalexin is a first generation Cephalosporin – a semisynthetic, beta-lactam antibiotic of a broad spectrum activity against gram-positive and gram-negative microorganisms.

Indications:

- upper respiratory tract infections (pharyngitis, otitis media);

- skin and skin structure infections (SSTIs) (streptococcal and staphylococcal skin infections);

- bone infections (osteomyelitis);

- genitourinary infections (cystitis, pyelonephritis, prostatitis);

- prevention of endocarditis (inflammation of the heart valve) caused by an infection.

MOA (mechanism of action):

Cephalexin is a bactericidal antibiotic which inhimits the bacteria cell walls synthesis. This results in the cell walls rupture and bacteria eventually die.

Cephalexin is active against aerobes gram-positive (Staphylococcus aureus (penicillinase-producing strains), Streptococcus pneumoniae (penicillin-susceptible strains), Streptococcus pyogenes); aerobes gram-negative (Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Moraxella (Branhamella) catarrhalis, Proteus mirabilis).

Dosage

Cephalexin is produced either in a form of dispersible tablets or in capsules.

Capsules are normally swallowed whole with water.

Swallow dispersible tablet with a drink of water, or first disperse it in water (5-10 ml), and then swallowed.

Treatment course is administered for 7 to 14 days.

Continue to take Cephalexin even if you feel well.

Do not stop taking Cephalexin suddenly.

For otitis media (middle ear infection):

Adults: The usual dose is 250 mg taken every 6 hours.

Children (ages 1–14 years): 75–100 mg per kg of body weight, taken daily in divided doses.

The doctor may double the dose in case of severe infection.

For skin and skin structure and bone infections:

Adults: 1–4 g per day taken in divided doses. The usual dose is 250 mg taken every 6 hours or 500 mg taken every 12 hours. If you have a severe infection, your doctor may give you a larger dose.

Children (ages 1–14 years): 25–50 mg per kg of body weight, taken daily in 4 divided doses.

The doctor may double this dose for severe cases.

For genitourinary infections and for pharyngitis:

Adults: the usual dose is 250 mg taken every 6 hours. If you have uncomplicated cystitis, you may be given 500 mg every 12 hours.

Children (ages 1–14 years): 25–50 mg per kg of body weight, taken daily in divided doses.

The doctor may double this dose for severe cases.

For endocarditis prevention:

Adults: 2 g taken 30–60 minutes before your procedure.

Children (ages 1–14 years): 50 mg/kg of body weight taken 30–60 minutes before your procedure.

The total child’s dose shouldn’t exceed the adult dosage.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not take a double dose of Cephalexin to compensate the missed dose.

Overdose

If an overdose occurs and you are not feeling well, stop taking the medication immediately. You should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Cephalexin are:

  • antibiotic-associated diarrhea
  • dizziness
  • fatigue
  • headache
  • joint pain
  • vaginal itching or discharge

Side effects occurrence does not only depend on the medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Cephalexin tablets if you are allergic to Cephalexin or to other Cephalosporins (e.g., Cefaclor, Raniclor, Cefadroxil, Duricef).

Do not take Cephalexin tablets if you are allergic to any ingredient comprised in Cephalexin.

Do not take Cephalexin tablets if you have a history of severe allergic reactions associated with using antibiotics.

Do not take Cephalexin tablets if you have a history of clostridium difficileassociated diarrhea (CDAD).

Do not take Cephalexin tablets if you suffer from an inherited metabolic disorder called porphyria.

Do not take Cephalexin tablets if you experience blood clotting problems and take anticoagulants (e.g., Warfarin), as taking Cephalexin may decrease the ability of blood to clot.

Do not take Cephalexin tablets if you take Metformin (for diabetes type 2 treatment), Probenecid (for gout and hyperuricemia treatment).

Do not take Cephalexin tablets if you experience problems with stomach or bowel (inflammation), kidney or liver, or if you have poor nutrition.

Patients with diabetes mellitus who test their urine for glucose should use glucose tests based on enzymatic glucose oxidase reactions while using Cephalexin tablets.

Do not take Cephalexin tablets if you are pregnant, plan to have a baby or are breastfeeding.

If you are taking vitamin supplements, do not take them for 2 hours before or after taking Cephalexin.

Q: What is Cephalexin used for?

A: Cephalexin is an effective and highly useful broad-spectrum antibiotic for the treatment of bacterial infections such as pharyngitis, otitis media, osteomyelitis, cystitis, pyelonephritis, prostatitis, streptococcal and staphylococcal skin infections. Cephalexin is not used to treat viral infections and fungi.

Q: Is Cephalexin safe?

A: Cephalexin is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q: Can I take Cephalexin for a cold?

A: Cephalexin will not work for viral infections like colds, flu and for mycoses.

Q: Does Cephalexin treat sexually transmitted diseases (STDs)?

A: Cephalexin is not approved to treat STDs. It may be used against staph infections, but is not very effective against bacterial vaginosis.

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