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About Ezanic® Cream

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Ezanic® Cream is manufactured by Intas. Applied to the skin, it cures acne and rosacea inflammations, as well as unclogs pores by removing dead cells from the skin surface. This cream is also used as an off-label treatment for melasma, non-resectable lentigo maligna, and cutaneous malignant melanoma. The active ingredient of Ezanic® Cream is Azelaic Acid, an organic compound of the dicarboxylic acids class. Azelaic Acid helps reduce pigmentation, so it is useful for darker skinned patients whose acne spots leave persistent brown marks (post-inflammatory pigmentation) or who have melasma.

Acne (also known as acne vulgaris) and rosacea are long-term inflammatory skin conditions. Acne is caused by P. acnes (Propionibacterium acnes) bacteria and characterized by clogged pores, pimples, whiteheads, cysts, comedones, and possible scarring on the face, neck, chest, and back.

Rosacea symptoms are flushing, redness, bumps, swelling, and visible blood vessels. It occurs when the human immune system reacts to the overgrowth of Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), in the skin. Overproduction of AMPs can be caused by blood vessel abnormalities, microscopic mites, and Helicobacter pylori bacteria among other reasons.

MOA (mechanism of action):

Azelaic Acid is an antibacterial, comedolytic, and exfoliating agent. It inhibits the synthesis of cellular protein and several oxidoreductive enzymes in bacteria. That prevents bacterial growth and reduces the amount of AMPs in the body, therefore calms down the inflammation. With normalizing keratin production, Azelaic Acid reduces the thickness of the stratum corneum (the outermost layer of the skin) leaving the skin free from pore-clogging dead cells and improving its appearance.


Ezanic® Cream is for external use only. Do not apply to your eyes, mouth, inside of the nose, private parts, and any other mucosal surface.

For acne: Apply Ezanic® Cream twice daily, in the morning and at bedtime. This cream should be applied for 1 month at least. Consult your doctor regarding the further use of Ezanic® Cream.

In case your acne has not improved after 1 month of treatment, discontinue the Ezanic® Cream use and seek medical advice.

For rosacea: Apply Ezanic® Cream twice daily, in the morning and at bedtime. This cream should be applied for 2 months at least. Consult your doctor regarding the further use of Ezanic® Cream.

In case your rosacea has not improved after 2 months of treatment, discontinue the Ezanic® Cream use and seek medical advice.

How to use Ezanic® Cream:

1. Wash your hands and the affected area with mild soap or cleanser, pat dry.

2. Apply a thin layer of the cream to the affected areas.

3. Rub gently until absorbed.

4. Wash your hands after the cream application.


If skin sensitization or irritation occurs, reduce the number of Ezanic® Cream applications to one time a day, preferably in the evening. After a week of such application schedule, start using Ezanic® Cream 2 times daily. If necessary, interrupt the treatment course for a few days during the irritation event.

Do not cover the cream application site with bandage or other covering.

Do not use Ezanic® Cream for longer than 12 months.

Do not use Ezanic® Cream more than 2 times a day.

Missing a dose

If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule. Do not apply a double dose.


Do not exceed the doctor's recommended dose. If an overdose occurs and you are feeling unwell, you should seek emergency medical attention or contact your healthcare provider immediately.


Store at a room temperature from 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away the tube after the expiration date. Keep away from children.

Side effects

The most common side effects associated with the use of Ezanic® Cream are:

  • burning or tingling
  • itching
  • abnormal redness of the skin (erythema)
  • scaling
  • dry skin
  • skin discoloration
  • irritation at the application site
  • oily skin
  • loss of skin color
  • discomfort or swelling

Side effects occurrence does not only depend on the medication you are using, but also on your overall health and other factors.


Do not apply Ezanic® Cream if you are allergic to Azelaic Acid.

Do not apply Ezanic® Cream if you are allergic to any of the other ingredients comprised in Ezanic® Cream.

Do not use Ezanic® Cream if you have asthma or herpes.

Do not use Ezanic® Cream if you are pregnant or breastfeeding without your doctor’s approval.

Do not use Ezanic® Cream in patients under the age of 12.

Do not take by mouth. Ezanic® Cream is for use only on the skin.

Q: Is Ezanic® Cream effective against rosacea?

A: Yes. Ezanic® Cream cures rosacea due to its anti-inflammatory and antibacterial properties.

Q: Can I use Ezanic® Cream during breastfeeding?

A: Although Ezanic® Cream is considered as mostly safe to use in nursing mothers, you should not start the treatment course without your doctor’s approval.

Q: Can Ezanic® Cream be used in teenagers?

A: Ezanic® Cream can be used in patients over 12 years old.

Target Point Shipping Method Tracking Delivery Time Price
Worldwide shipping

Worldwide shipping

Registered Mail  Not trackable 14-21 business days USD 20.00 per order
EMS  Trackable, where available 5-9 business days USD 30.00 per order

Delivery time is:

Registered Mail - 14-21 business days, price - USD 20.00, no signature is required on delivery.
EMS - 5-9 business days, price - USD 30.00, signature is required on delivery.
Your order will be packed safe and secure and dispatched within 24 hours.

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This is exactly how your parcel will look like (pictures of a real shipping item). It has a look of a regular private letter and does not disclose its contents. Size - 9.4x4.3x0.3 inches (24x11x0.7cm).

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