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About Rebetol (Ribavirin)

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Also known as:  Ribavirin.

Description

Rebetol is an anti-viral drug indicated for severe RSV infection, hepatitis C infection and other viral infections.

Rebetol is manufactured by Merck Sharp and Dome (a subsidary of Merck and Co., Inc.).

The active ingredient, Ribavirin is a professional grade drug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for replicationRebetol.

Ribavirin helps the immune system fight the virus and makes it harder for the virus to reproduce within the body.

Rebetol is prescribed in combination with other medications such as sofusbuvir and peginterferon alfa 2a/2b for preventing hepatitis C virus (HCV) cells from multiplying in your body.

Treatment of HCV genotypes 1, 2, 3 and 4 is possible with Rebetol, however it is never used on its own.

Dosage

Take Rebetol with food.

The recommended dose and duration of Rebetol ranges between 800mg to 1400mg/day depending on how much the patient weighs and the medicines that are used in combination.

- 800 mg/day: Take 2 Rebetol 200 mg tablets in the morning and 2 tablets in the evening.

- 1000 mg/day: Take 2 Rebetol 200 mg tablets in the morning and 3 tablets in the evening.

- 1200 mg/day: Take 3 Rebetol 200 mg tablets in the morning and 3 tablets in the evening.

- 1400 mg/day: Take 3 Rebetol 200mg tablets in the morning and 4 tablets in the evening.

Rebetol is prescribed in combination with other medications such as Sofusbuvir and Peginterferon Alfa 2a/2b for preventing Hepatitis C virus (HCV) cells from multiplying in your body.

Treatment of HCV genotypes 1, 2, 3 and 4 is possible with Rebetol, however it is never used on its own.

Missing a dose

Rebetol is used only when needed, therefore missed dosages are not relevant. Do not take a double dose of Rebetol.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Rebetol has side effects. The most common are:

  • nausea, flu-like symptoms, tiredness
  • fever, chills or shaking
  • headache
  • mood changes, feeling irritable
  • muscle pain
  • stomach pain, vomiting, loss of appetite

Less common but more serious side effects during taking Rebetol:

  • vision problems
  • severe upper stomach pain spreading to your back
  • nausea, vomiting, diarrhea
  • stabbing chest pain, wheezing, feeling short of breath
  • severe depression, thoughts about suicide, or thoughts about hurting someone else
  • signs of serious anemia--pale or yellowed skin, dark colored urine, confusion or weakness
  • other signs of low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, easy bruising

Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Rebetol if you are allergic to Rebetol's components.

Do not take Rebetol if have a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia, autoimmune hepatitis, severe kidney disease, severe liver disease other than hepatitis C (especially cirrhosis).

Be careful with Rebetol if you have heart disease, breathing problems, vision problems, a thyroid disorder, human immunodeficiency virus (HIV or AIDS), diabetes, a history of depression, mental illness, or suicide attempt, or a history of organ transplant.

Do not take Rebetol if you are also taking didanosine (Videx), azathioprine or medicines to treat HIV or AIDS.

Use at least 2 effective forms of birth control to prevent pregnancy while either sexual partner is taking Rebetol. Keep using 2 forms of birth control for at least 6 months after treatment ends.

Be careful with Rebetol if you are pregnant, planning to become pregnant, or are breast-feeding.

Rebetol is contraindicated in men whose female partners are pregnant.

Do not use Rebetol in treatment of children under 18 years old.

Do not drive or operate machinery as Rebetol may make you drowsy, dizzy, or confused.

Take necessary precautions as Rebetol does not prevent the spread of infection to other people through sexual contact, sharing of needles or contact with blood.

Drink extra fluids to stay hydrated during treatment with Rebetol.

Q: What is Rebetol?

A: Rebetol is in a class of antiviral medications called nucleoside analogues commonly used to treat hepatitis C and severe acute respiratory syndrome (SARS).

Q: How does Rebetol work?

A: Ribavirin, which is the antiviral active substance of Rebetol, inhibits the multiplication of many types of viruses, including the Hepatitis C viruses. It helps the immune system fight the hepatitis C virus, and makes it harder for the virus to reproduce within the body.

Q: Is Rebetol monotherapy effective for the treatment of chronic hepatitis C?

A: Rebetol monotherapy is not effective for the treatment of chronic hepatitis C virus infection and should not be used alone for this objective. Rebetol should be used with such medication as sofosbuvir (Hepcinat) or peginterferon alfa-2a (Pegasys) or peginterferon alpha-2b (PEG-Intron) to treat hepatitis C.

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